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posted by jcvaughn26

First let me preface by saying that insulin IS NOT for newbies.... gain weight with AAS first.... then try this.... This is an informative article, but it is not the end all. Research your ass off... And finally.... I am not a doctor.... so use this as a guide.... Also I do not mind if this gets posted else where... just give me credit Insulin and all that it entails. Chemical structure Insulin is the hormone that is released by the beta cells of the pancreas. It is the hormone that regulates blood glucose levels. It is a polypeptide that is made up of a chain of 20 and 31 amino acids, thus a total of 51 amino acids. This nifty little hormone just so happens to be the most anabolic hormone in the body. Actions of Insulin In addition to its role in regulating glucose metabolism, insulin stimulates, lipogenesis (the formation of fatty acids from acetyl coenzyme in the living body), diminishes lipolysis, (the hydrolysis (breakdown) of fat). It also stimulates the uptake of amino acids contributing to its overall anabolic effect. We as bodybuilders should be interested in that. Insulin also modulates transcription, altering the cell content of numerous mRNAs. It stimulates growth, DNA synthesis, and cell replication, effects that it holds in common with the insulin-like growth factors (IGFs) (1) For our bodybuilding needs Our reason for using insulin is to use its abilitiy to shuttle nutrients to the muscles at a very high rate. It shulltes large amounts of protein and sugars to the muscles for fuel, repair, and growth. The ability of insulin to transport nutriants is what makes it perfect for our needs and goals. More nutriants is simply more muscle mass. The use of Insulin for bodybuilding purposes There are a few types of insulin available to the public, these I feel are the only ones that apply for our needs. Humalin R*, Duration ~10-12 hours, peaks at 3rd hour until the 5th hour Humalog* Duration ~6 hours, peaks at 80min to 120 min. Nolvalog, Just a different maker of a fast acting insulin, same times as humalog. Few notes, Duration is the amount of time the chemical is active. Peak time, is the time in which you have the highest level of the chemical in the blood (2) *This is for subcutaneous (subc, or subq) injections... we as body builders do not use insulin this way. We should and need to shoot intramuscularly (IM) see below. Knowing what you know about the duration and peak times of humalog shot subcutaneous. Below is a graph to represent how humalog shot IM affects the blood glucose levels. T= -5 is post w/o before insulin T=0 is 10IU Humalog IM into left bicep T= 5 is BG prior to my ingesting 85g of dextrose, 5g of glutamine and 7g of creatine T=35 is BG prior to ingesting 80g of whey T=105 is BG prior to 25g of dextrose and 150g of chicken breasts After 150min past an IM Humalog injection, the BG remains stable First off the warnings... -Insulin is dangerous. Yes you can die from it, you can have some serious complications. But my goal is to educate you enough to where you never have to worry about these problems. -Hypoglycemia- symptoms include disorientation, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea in NO paticular order. This can and WILL happen to you... so be prepaired. How to use it for our needs... Once you are finished with your work out, get the hell out of the gym to take your shot. Do not look around for a new girl to talk to.... get your ass home. Once you are home, and this is your first time using it, start off with 4 IU. Every PWO there after add one more IU, until you hit 10iu. Then follow the diet below Diet- 10min after your shot, injest the proper amount of dextrose* and 65-90G of whey isolate protein in WATER One hour after your shot have your PPWO meal. This meal is a solid one. (no shakes) 40-50g of protein, 40-50g of carbs, NO FATS Also avoid fat at all costs for the next two and half hours. Remember if insulin transports AA and protein at a high rate, it will also transport fat**.... you have been warned *You simple carb ratio should start off at a very safe, 10g of carbs per 1iu of insulin. So if you are at 7ius you need 70g of dextrose. **But I dont wanna get fat :fit: - Hey neither do I.... so to avoid this complication once you get to your 10ius of insulin and everything is good. Lower your carb to slin ratio SLOWLY. Once you feel funny, you are too low. This varies from person to person... I feel hypo at 7g/iu.... some of my buddies can go 5g/iu. So proceed with caution whenever you try to figure this stuff out. Things to remember- -This HAS to be cycled 4 weeks on, and 4-6 weeks off. Otherwise your insulin sensativity will go down and you cound have some problems. This is where you could become insulin depdent...... bad news! -Its a good idea to have a partner around that knows that you are on insulin... Just incase something happens then can be prepaired to help you out. -Have all of your supplies with you ready to go before you take your shot. I live close enough away from the gym where I can drive home and shoot at the house. But some of you do not have that luxery. So if you shoot in the car or in the locker room, make sure you have your dex/whey drink. Along with some sweetarts, dextrose tablets or even a soft drink. That way if you do come across a problem (going hypo) you can stop it before it really starts. - Do not exersize while the insulin is active... it will throw off your glucose levels and cause you to go hypo a lot easier. - Do not go to sleep whenever the insulin is active, seems like common sence to me but I just want to say it. If you are asleep... you have NO way of knowing if you are going hypo.... so STAY AWAKE! - Do not shower while the insulin is active.... makes it very hard to determine if you are going hypo.... trust me I know : - Hypoglycemia can happen VERY fast... so make sure you are ready to fight it IF it happens. Things you need to do prior to using insulin, once you feel you are ready. -First you need to get a blood glucose meter... if you do not have one, do not mess with insulin, period Second, once you get your BG meter, check your BG first thing in the morning when you wake up. This will be YOUR personal baseline. Test this for a few days to see what your levels are. Third- It would be a good idea to eat like you would on insulin and check your BG PWO. You just have to check it once.... 15 min after your dex/whey shake is great. These are just precautions.... Im trying to save your butt here. Some questions- -I can only get Humalin R in the states.... can I still use it? Yes you can, do I recommend it? No way... did you forget what you just read If you want info on how to get humalog... shoot me a PM -Can I get away with using an insulin pin to inject IM? Sure you can, make sure you shoot into an area of low body fat. IE bis, tris and for some delts and quads. -Can I use this to cut? Yes you can, but this is for an advanced user. Chances of hypo increase whenever this is done. See rambos sticky. -Can I bulk with it? You bet you can.... and its EASY. Just up your carb intake to 12g+ per IU and you will be gaining in NO time. -Can I use this in PCT? shoot yeah you can and its a very good idea. This is a great way to keep some of the mass you have gained in your AAS cycle. -Can I add supplements to my PWO shake? Yes, I add 1.5g of CEE (creatine ethyl ester) as soon as I take my shot. Also you can use glutamine, but you need to split up your shakes.... so 5 min after injection, you have your glu+dex drink. 10min after that you have your whey iso drink. FWIW I do not use glutamine. -Do I need to use insulin twice a day? IMO no... the only time you have to have it is PWO. But some use it in the morning to fight of catabolism... If this is what you want to do, use a small amount ie 4-6iu. Insulin use with LR3 IGF-1 I am writing this for the seasond insulin and LR3 user LR3 makes you more sensative to insulin. So even if you know what your carb ratio should be.... up it. And lower your initial intake of insulin. Start at 7iu, and with a 10g of carbs ratio. Work up or go to 10ius... keeping your dex high. Then lower it accordingly. If you are using both, hypo comes way faster than it did before.... I have had to keep my carbs over 9g... So just be careful. Increasing your Insulin sensativity There are a few ways that you can go about to accomplish this, OTC or prescription. OTC -ALA any form of it but Kr-ala is the best, as it does not break down thanks to the potassium. The dosage is around 400mg-600mg... and add some biotin. For more on this visit the supp section.... -GTF Chromium or Chromium Piccinolate at 300-400mcgs. This stuff is cheap so get some. By prescription- -Actos this med comes in 15mg 30mg and 40mg tablets... for the average person with lowerd sensativity, 15mg will be enough to bring it back to the normal range. Blood Glucose Ranges (mg/dl) Taken first thing on the morning (fasting for 8+ hours) 70 - 110 mg/dl - normal range this is individualistic. 110 - 126 mg/dl - impaired tolerance range. This means you need to monitor closly as becoming a diabetic is a prolbem. 126 - above mg/dl - You are a diabetic.... Types of Diabetes: Type 1 Diabetes is caused by a total lack of insulin that, in turn, produces high blood glucose levels. Type 1 is most often is seen in children, but can develop in adults. If you have Type 1, It would be a good idea to have your blood sugar checked regularly. Type 2 Diabetes occurs when the body does not produce enough insulin or cannot properly use insulin. This is the most common type. The treatment may be similar to Type 1. Brought to you by your aspiring insulin guru MS

posted by jcvaughn26

How to use insulin - the most anabolic hormone Directions for first time insulin users This is an article I wrote a little while ago and posted on several boards. I know its a long post but take the time and read it because your life does in fact depend on it. There are a couple other articles on the Anabolic Review board in the Hot Topics Section but I think they all pretty much have the same info. Let me know if you have any questions Insulin is the most anabolic hormone you can take. On the other hand its also one of the most dangerous for two reasons availability and ignorance. I will be the first to tell you that every time I have been hypoglycemic (when blood sugar drops to dangerous levels) its has been as a result of something I did wrong. Used responsibility and with respect for the potential sides it is quite safe and extremely effective. That being said we'll start off with what you are going to need. Equipment: There are several types of insulin out there but for our purposes we are only interested in two. The first being my favorite Humulin R and the other being a bit newer to the body building community Humalog. Humulin R is the most widely used and time tested insulin in our arsenal. It has a max duration of 4hrs and its peak can been seen around 2hrs after injection. This becomes particularly important when planning out you meals for the day so keep the timetables in mind. Humalog is a bit newer but some feel just as effective and a bit safer. Humalog has a max duration of 2hrs and its peak can be seen around 1hr after injection. When selecting to use one or the other keep in mind your schedule, meals, and physical activity for the day as it will all play a role. One other point that needs mentioning is that Humulin R is available over the counter at pretty much every pharmacy in the country for about $25 for 10ml (which will last you a very long time) and Humalog is available only through a prescription or over the black market for a price about double that of Humulin R. When approaching a pharmacist keep in mind that its a lot more convincing if you buy the needles at the same time you get the insulin. This way they are less likely to refuse to sell it to you which they have been known to do from time to time. If this should happen just continue on to the next pharmacy and despite what they tell you "you dont need a prescription" it might be their store policy to see one but legally it is not required and if you make enough of a fuss you will get what you need. The next thing you will need is the actual needles for injection. These are not the same type that you would use for anabolics or other androgens. The type of needles you will need are U100 insulin needles. That is exactly what you need to say when are trying to buy them. A box of 100 will usually run about $15-$25 and again will last you quite a while. Be fore warned now, using a syringe labeled with cc/ml or anything other than u100 is potentially fatal. The difference between the amount of insulin used for our purpose and that which will kill you is less than 1/2 a cc. The next two things I think you will need and I highly recommend having on you is a wrist watch with a chronograph (stopwatch) and glucose tabs and/or a can of soda. First I'll explain the wrist watch. The stop watch is to be started immediately after the injection and monitored periodically to keep track of what is in your body and how long it is active. This can also be used to determine whether or not you are feeling side effects or simply just nerves from the fear that follows using for the first time. For instance I always use Humulin R which we know has a duration of 4 hours and a peak at 2 hours. This means that the greatest effects will be felt somewhere between 1-1/2 to 2 hours after injection and then they will steadily lessen till it is no longer active 4 hours after injection. When you use a stopwatch you have an accurate record of when you felt the effects which will become more important as you get more experienced using insulin. The glucose tabs are your safety net. If you are feeling hypo (hypoglycemic) these tabs will return your blood sugar levels to a safe range where you can get some food. They are available at all pharmacies for about $1.00. I have also used a soda. Soda is high in simple carbs which act quickly when blood sugar is low and allow you to get to a safe range where you can get some food in you. Now that we've covered all the equipment needed to safely use insulin we'll move on to dosage diet and scheduling. Dosage diet and scheduling: Whenever you start insulin its always wise to start at a lower dose and taper up over the first couple of days of use. Insulin is still new in our community and there is a potential for becoming diabetic so dont take chances start small more is not better where insulin is concerned more is simply more fat and more dangerous. This is a schedule I use when just starting insulin: day1: 5iu's post workout day2: 6iu's post workout day3: 7iu's post workout day4: 8iu's post workout day5: 9iu's post workout day6: 10iu's post workout day7: same as day 6 This concludes week once from here on out this is how I proceed. If I am going to be increasing my dose even further. day8-10: 10iu's morning, 10iu's post workout day11-14: 10iu's morning, 10iu's noon, 10iu's post workout day15 and on: increase post workout dose till I start to feel symptoms of hypoglycemia and then back the dose down accordingly. THIS IS ONLY FOR ADVANCED USERS, DONT EXCEED THE DAY 7 DOSE TILL YOU GET SOME TIME UNDER YOUR BELT. I AM NOT KIDDING YOU WILL DIE!!! Your diet will depend on the amount of slin you take per injection. The rule is 10 grams of carbs per IU of insulin. Therefore if you take 10iu's at an injection you need 100 grams of carbs. This is a bit overkill the actual figure is about 5-7 grams but its best to stick with the 10 rule while starting out. I feel that the best most accurate way to consume the proper amount of carbs after an injection is through MRP's or other shakes. The amounts of carbs on these are far more accurate than those you will find on the back of a bread bag. My meals are usually layed out like this: 7am: 10iu's insulin, shake 9am: shake 12pm: 10iu's insulin, lunch 2pm: shake 4pm: shake 6pm: workout 7pm: 10iu's insulin, shake, higher in carbs than others 9pm: dinner 11pm: safe for bed If you'll notice there is a method to the madness above. After taking your first injection if insulin you will need a shake immediately. After this you are good for the next 2 hrs till the insulin peaks. Once you hit the 2hr mark you will need more carbs either another shake or a meal with sufficient carbs. After you have cleared the 4hr mark you will be clear from danger. Now this is all based on using Humulin R. If you are using Humalog you will need to take your first meal after injection and another "1hr" after. Then after the 2hr mark you will be safe. My shakes are made up of 1/2 pack of MetRX (berry) and 2 scoops GNC brand weight gainer (vanilla) and 16oz of whole milk. This shake has a caloric value of about 800 cals and around 50grams of protein and 150+grams of carbs. This is a good meal for those starting out. As you progress though you will want to decrease the carbs and eliminate the fat completely to maximize lean mass gains and minimize water and fat retention but for the purposes of starting out simply taking T3 will offset any fat gained. One thing to keep in mind is that T3 will reduce your sensitivity to insulin allowing you to take a higher dose but again save this till you get some more time in. Side effects and procedures: After injection and starting your stopwatch your first task is to get some carbs in. Next the first sides you will feel is tired. This is normal and is to be expected. You will usually feel this somewhere between 15-30 minutes after your injection. The key here is not to sleep, if you sleep you wont feel further more dangerous sides and therefore you wont be able to save your ass. The next thing you need to do is have another meal/shake at the 2hr mark. If you miss this just get it in as soon as possible. If you delay long enough you will start to feel hypo around 3 to 3-1/2 hours after injection. When this happens you will feel a sort of numbness that I can only relate to ephedrine. After this you will start to get some shakes in your hands followed by a cold sweat. Once you get to this point you are full blown hypo, the next thing that will follow will be a bit of tunnel vision and this is as far as I’ve been after this its all textbook I imagine coma will follow shortly after passing out. When you get the symptoms listed above don’t hesitate. Get some soda/glucose tabs followed by a meal or shake. One other fact I neglected to mention is that a mix of carbs is necessary when consuming a meal. Simple carbs are used to quickly and complex don’t kick in fast enough. A good mix is the way to go. This is pretty much a beginners guide to getting started on insulin. If you have any questions either post them on the board or email me. No question is stupid when it comes to a potentially fatal drug. Good luck and get huge. This was originally posted on AF by Juice Junkie.

posted by jcvaughn26

Originally written by RedBaron If you are a seasoned insulin user, this post is going to be WAY too basic to be of value to you. The purpose of this post is to answer the very basic questions for those completely unfamiliar with insulin and its use in the body and for bodybuilding purposes. There are a lot of post about insulin and how it is used for bodybuilding purposes. But more basic than this, I am frequently asked....what exactly is insulin and what is it really doing for my body. Here is just a REALLY basic overview of what insulin is in the most basic of terms. What is Insulin for? Your body's main source of fuel is a form of sugar called glucose. It gives us energy. After we eat, glucose enters the bloodstream and signals a gland near the stomach, the pancreas, to make insulin. Insulin is a chemical that helps cells in your body use glucose. As cells use glucose for energy, the level of glucose in the bloodstream drops. If there is no insulin or the insulin isn't doing its job too much glucose builds up in the bloodstream. This is the condition you find when you have diabetes. Basic Types of Insulin There are many different types of prescription insulin. Some are designed to work right away and don't last very long. Other types act more slowly over longer periods of time. Doctors routinely prescribe the type of insulin that matches your body's needs for diabetics. This is why you see so many different brands and types on the market. Depending on the symptoms and condition of the diabetic, the insulin type is tailored to their needs. Bodybuilding use of Insulin Now let's cut forward to all of us that are NOT diabetic. Our reason for using insulin is to use its inherent shuttling abilitiy to shuttle nutrients to the muscles. For our purpose we are not trying to achieve long term control of glucose buildup in the bloodstream. We are trying to transport supraphysiological amounts of protein and sugars to the muscles for fuel, repair, and growth. For our purposes, we want to use a quick acting, short lasting insulin. As we learned above, insulin's purpose is to pull glucose out of the bloodstream and ship it out ... helping cells use it. The problem with this is the brain has a really, really small limited range of blood sugar levels that it will function within. If we put too much sugar into our system uncontrolled by insulin, we check out for good. If we have too much insulin and our blood sugar drops too low, same result....we check out. This is the danger that is inherent in manipulating insulin for our bodybuilding purposes. This is also why the timing of carbs immediately after insulin injections is critical. What, When, and How? For the purpose of bodybuilding, we want to use a short acting insulin (such as Humalog, or if not available next best Humulin-R). The dose required will end up being between 4-10 IU's. The most advantageous time to use this is immediately post workout, when our muscles are screaming out for nutrients and are in a catabolic state. We use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject sub-q if desired. When starting out using insulin, begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your desired maximum. Immediately following your injection, you will want to do the following religiously: injection + 5 minutes – drink shake with 10g glutamine / 10g creatine / 55g dextrose Injection + 15 minutes – drink shake with 80g of whey protein in water Injection + 60 – 75 minutes – eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS Avoid fats for 2-3 hours for Humalog IM, 3-4 hours for Humalog sub-q, 4-5 hours for Humulin-R. Things to Watch for Insulin's most commons side effect is HYPOGLYCEMIA(low blood glucose). It is important that you know the signs of hypoglycemia they may occur quickly! They are: - Shakiness - Anxiety - Fast heart beat - Hunger - Sweating - Blurred vision - Dizziness - Weakness - Headache - Irritability If any of these symptoms occur, you should eat some form of quick acting sugar to prevent the symptoms from getting worse (e.g., two or three glucose tablets, one tube of glucose gel, one-half cup of fruit juice or regular soft drink, one tablespoon of honey, or one tablespoon of sugar dissolved in water) Always have something like the above on hand when using insulin. Hypo symptoms can and will hit hard and fast, and you will have a very small window of time to react. Be ready!! Well, hopefully you now have a basic understanding of insulin. There are many other in-depth articles and studies available that I would encourage you to read and study, especially before venturing into insulin use. While it is extremely useful for bodybuilding, it is also dangerous enough to not be taken lightly.....know what you are doing and have a plan BEFORE you begin to consider using insulin. As in anything we do, research, research, research!!! Hopefully this post will whet your appetite to look into insulin.....used properly it is definitely one of modern bodybuilding's great tools.

posted by jcvaughn26

First Insulin Injections After reading a few informative posts by some reputable bros, I used the search engine and studied how I could use Insulin to help sent my carbs, protien and creatine straight to my muscles like a Ferrari. My first injection was a small experimental dose of 5iu and the second at 10iu. I quickly noticed how fast you could feel it in 10-15minutes. I felt like I was a little stoned until I got enough carbs/glucose in my system. I've noticed a little pump too. I would have used Insulin sooner, but I always thought you needed a prescription and you dont. At least I didnt feel as uncomfortable buying U-100 Insulin syringes as I did buying 18g needles and 25 gage syringes... Credit Monster for this post and BigWh1tey for his repost of Monsters that I found. Ok, lets have a look at insulin. Its highly anabolic and non-androgenic, and in case some of you are in the dark (I'd like to think we're all clear on anabolic versus androgenic, but ya never know) I'll briefly touch on the subject before diving in... if youre ok on anabolic/androgenic concepts, skip to the INSULIN part... ANDROGENIC VERSUS ANABOLIC ANABOLIC is defined as "The process of constructive metabolism" or of building complex substances out of simple substances. The way your body processes protien, carbohydrates, and fat (all simple substances) and makes muscle (a complex substance) is ANABOLISM. ANDROGENIC is basically defined as pertaining to male sex characteristics. ANDROGENIC/ANABOLIC "Steroids" are actually called "Anabolic Androgenic Steroids." They accomplish "anabolism" through "anabolic" pathways, some being more androgenic (testosterone esters) and some less (winstrol, anavar, primobolan, ect...). Most often, with reduced androgenic properties comes reduced anabolic properties, but it isnt always cut and dry. If anyone is interested I'll go into it another time, but lets head toward the insulin topic. INSULIN: NonAndrogenic but Anabolic Insulin is NOT a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands... WHY IS INSULIN ANABOLIC So why is insulin anabolic then? Insulin is a partitioning agent. A "shuttle" if you will. Picture insulin as a bus. Nutrients board the bus, and insulin pulls away and drops off the nutrients at the proper bus stop. That is basically what it does, and for all intents and purposes that is everything you need to know to understand how it works. So by insulin shuttling these nutrient where they need to go, it enables anabolism and is therefor anabolic! WHY NOT JUST TAKE CARBS TO RAISE INSULIN Well, the amount of carbs you would need to take in to increase natural insulin levels to the degree a 10 i.u. shot would would be far more dangerous than using insuiln (and using insulin is NOT that hard OR dangerous). Carbs at that level would eventually lead to diabetes and fat gains. If insulin is a bus taking nutrients where they need to go, then exogenous insulin is a bullet train! It can hold far more nutrients than a normal naturally produced burst of insulin can, and it works quicker. Exogenous insulin is the most efficient way to accomplish glycogen overcompensation, period. WHAT KIND DO I TAKE Im a major supporter of fast acting insulin. The faster the better! Currently he fastest acting insulin available is Humalog. It is active in 15 minutes, peaks in 1 hour and clears the system around 2 hours. Next would be Humalin-R. It is active in about 30 minutes, peaks at the 2 hour mark, and clears the system at the 4 hour mark. "Biophasics" are mixtures of fast and slow acting insulins, but are not the best choice in my opinion, due to an active dose being in you throughout the day. The reason you dont want that will be covered in the "HOW DO I USE IT" section. There are also Humalin-L and Humalin-S, but they are long acting, and are no more use to me than the Biophasics. There are also porccine and bovine derived insulin, but I am against injecting animal derived substances. WHEN (AND HOW MUCH) TO USE Im going to assume we want to avoid any fat gains at all. Even bulking I dont like to gain any unneccesary fat, so Im going to disuss it from that stand point. The ultra conservative time to use insulin is post-workout. Most people who are concerned about fat dont go over 10 i.u. as a total dose. Some people us it on waking, before breakfast, since your body is in a basically carb depleted state. Its the kind of thng you have to try for yourslef, and if it works for you, do it. If you thnk youre gaining fat, stop. BUT! Dont start it at both times at once. Make sure you get your post workout dosage worked out and that you know it is not causing you any fat gains before you try pre-breakfast shots. That way you can take out all the guess work as to where any fat gains may come from. DISPELLING A FEW MYTHS There is a commoly held perception that you MUSt take in 10grams of carbs per I.U. of insulin, some radicals say 5 grams... well, theyre both wrong. I got curious about this when I discovered that my insulin dependant diabetic friend didnt even keep track of what she ate post injection. She would feel hypoglycemic after a shot and take a Glucose Tablet. A glucose tablet is only 5 grams of glucose (carbs)! So I started to think, "Hmmm, mabye everyone is off point on this?" After conducting a few experiments on myself, I found that you can go considerably lower in carbs than people previously believed. Now it doesnt make sense to go low in carbs, because that defies the purpose of using the insulin in the first place, but it does free us from having to use so much that there might be some "spill over" in carbs that cant be utilized. So it really makes us able to have more freedom in carbs choices and amounts. The "risk" in insulin use is not as risky as people believe. Any person with an ounce of sense can see the warning signs of a problem coming, and remedy the situation. HOW DO I DO IT If you look at the drug store, you can get these little pen cases that hold a loaded insulin syringe. They are great for our need, you load up the syringe, and put it in the case, and throw it in your bag/purse/whatever. After the workout, head to a bathroom stall and inject it under the skin! Pull up a little skin from the abdomen or upper thigh (anywhere will do, but these are easiest) and inject. Do not shoot into a muscle. This rushes the dose and makes it harder to predict when it will spike. So now you have 15 minutes to get some carbs (actually you have longer, since the initial hit of the dose is mild and easy to cope with, the spike is a little more harsh, but still nothing unbearable. If you use the carbs, you probobly wont notice the initial dose OR the spike.) (this is based on Humalog at 10 i.u.) I use a powder with a 20% simple/80% complex ratio (actually its 17% mono, 5% di, 7% tri, 5%tetra, and 66% penta-saccharides). I use about 60grams of carbs to the 10 i.u. of insulin. This gives me a nice solid stream of carbs to overcompensate my depleted muscles, but not so many that I risk fat accumulation from the excess. Now you are good to go till around 1 hour after the initial injection. At this 1 hour mark, the majority of the dose hits your system. Now is the time to eat a good balanced (AND FAT FREE!) meal. The fat-free emphasis will be explained in the POTENTIAL PROBLEMS section. This balance meal of carbs and protien and little to know fat can be anything from a protien drink and a crab drink, to a low fat MRP, to some lean chicken and rice... your choice. After this meal, you dont need to pay anymore consideration to the insulin, it will gradually decrease and will be out of your system at the 2 hour mark. Till you get accustmed to the use of insulin, start low and slow. Start at 2 i.u. then 5 i.u. then 7 i.u. then 10 i.u. That way you get a better understanding of any hypoglycemia you may encounter. Ive went as high as 35 i.u., just to try it, but at a certain point a higher dosage doesnt yield any better results (except fat!) POTENTIAL PROBLEMS Insulin is relativly safe. If you dont take in any carbs after using it, your body will give you PLENNTY of warning! Youll feel dizzy, tired, achey... hypoglycemic. What is happening is your body has no glycogen to use as fuel. Your muscles re depleted from working out, and often times youve tapped your liver for any remaining glycogen. The insulin does, searching for glycogen to use, takes the rest from your liver, and in the absence of carbs coming in to make more, it heads for the brain. Your brain uses glucose as its primary fuel source (a little fat, too.) Thats why you get dizzy and light headed, the same with during a ketogenic diet... low glucose equals light headedness. So if you forget about the carbs, youll get a warning from yuor body, and you can get your ass in gear and get some carbs in you. If you get to the point where youre nauseated, just drink some sugary beverage and get some carbs in you quickly. Youre still a long long way from any major danger, but dont mess around. "Fat Free" I said earlier about the 1 hour mark meal. During the 2 hours of the dosage duration, you should avoid fat like it is the plauge! Insulins partitioning properties are as effective at sending fat to the fat stores as it is carbs and protien to muscles! So till the dose is clear of your system, NO FAT! (Thats another reason why I advocate the fastest acting insulin you can get.) - Monster

posted by jcvaughn26

By AnabolicDiabetic (EF) BASIC Insulin Primer- READ BEFORE POSTING QUESTIONS PLEASE WHAT IS INSULIN? Insulin is a hormone produced in the pancreas- islet cells/beta cells to be specific. Insulin facilitates the use of sugar, which all calories are ultimately converted to, for the multitude of bodily fuctions which include energy production, brain activity, metabolism regulation- basically all of your body's function either directly or indirectly. WHERE DO I GET IT AND WHAT TYPE DO I USE? Humilin R is available OTC just about everywhere and while it is a quick acting insulin, it is not the fastest or most consistent in terms of absorption and effect. Humilin R starts working in about 1/2 hour and the effect can last up to six hours. Humalog is available OTC in some states/countries while be RX only in many other states. Humalog is a true fast acting insulin which begins activity within 15 minutes and ends activity within 4 hours. Humalog is the preffered insulin to use since it works more predictably and is out of your system faster which makes it easier to control. HOW MUCH DOES IT COST? In general, Insulin costs between $20-$30 depending on the type and where you buy it. WHAT KIND OF NEEDLES DO I USE? Use 29 guage, 1/2cc insulin syringes. "B-D ultra-fine" is my preference in terms of brand. WHERE DO I INJECT? Upper back of arm, abdomen(avoid area too close to belly button), inner and outer upper thigh, butt cheeks. HOW DO I INJECT? Rotate injection sites each time you inject. Don't inject into the same area two times in a row. Insulin injections are subcutaneous- not intramuscular. WHAT DOSE DO I START WITH? Start with 2-3 units of insulin. There is no need to start higher than this as you will be adjusting your dose gradually to find a tolerable level. HOW DO I INCREASE MY DOSE? To move your dose higher in order to find your ideal dose, go up by one unit per day. A very general guide would be to consider between 10 and 15 units as your pre-determined upper limit. If it turns out you want to go higher and don't have any trouble with those doses, then no harm is done and you can go higher. Don't make big leaps up in dose or assume more is better- be safe rather than sorry. WHAT DO I EAT AND WHEN DO I EAT IT? For Humilin R, the general start of activity is within a 1/2 hour but the varies ALOT!!!!! Don't assume you have tons of time to wait to eat simple sugars. Pay attention to how you feel and never wait more than 15 minutes(if that) to eat. First consume simple sugars(dextrose preffered but not the only one) in the form of some type of drink as these are most readily absorbed in my experience. A general guideline is 10 grams of carbs for each unit of insulin- MINIMUM! Within a hour or so after your dose you want to eat a mix of simple carbs and high protein- this is the golden hour AFTER your workout when the insulin will shuttle nutrients into your muscles very efficiently. Humilin R will peak at two hours after you take it so you must eat another balanced meal at the hour and a half mark approximately. This meal should include complex carbs, some fats, and protein. Use simple carbs also if you feel any hypoglycemic symptoms. "R" will last up to six hours so be aware of how you feel and eat as needed after the two hour mark. REMEMBER THAT YOU STILL HAVE A SIGNIFICANT AMOUNT OF INSULIN WORKING UP TO SIX HOURS LATER SO DON'T BE COMPLACENT AND ASSUME YOU'RE NOT GOING TO GO HYPOGLYCEMIC. For Humalog, use the same general rules and type of meal sequence, but begin the process immediately. Simple carbs should be ingested within 10 minutes- NO EXCEPTIONS. Then have the carb/protein meal within the hour. Then have the balanced meal of complex carbs/fats/protein at the hour 1/2 mark. Keep aware of how you feel up to four hours after your dose and eat as needed. FACTORS AFFECTING INSULIN ABSORPTION/SENSITIVITY The abdomen is generally the area where insulin is absorbed the most consistently or evenly as it is designed to be. Injections near a muscle that you have worked out can dramtically increase the absorption rate and effect of your dose of insulin. GH will make you more insulin INsensitive so your tolerance of insulin will change when on or off of GH. Highly androgenic steroids also make you more insulin insensitive, however, can also cause very random hypoglycemia aswell. Supplements such as Chromium, Ginseng, Alpha Lipoic Acid, and Cinnamon (among others) increase insulin sensitivity. Variations in glycogen levels in your muscles can also affect how severe a hypoglycemic reactions may be or may feel. If you are starting out with low levels of muscle glycogen, the same dose of insulin that didn't affect you before may now be too much. The glucagon response from everyone's liver will vary. This hormone increases blood sugar when during stresses to the body or in response to hypoglycemia. Some people may get a big response from their liver and hypoglycemia for them won't be as severe. Others will have less of a respense and may be more prone to insulin shock. This response can also vary for each person based on their diet, exercise etc. so don't assume your liver will react the same way to hypoglycemia each time- you may get help from it or you may have to depend mostly on consuming sugar to save your life. WHAT ARE THE SYMPTOMS OF HYPOGLYCEMIA? They include: sweating, dizziness, heart palpitations, tremors, drowsiness, sleep distrubances, anxiety, blurred vision, hunger, restelessness, lightheadedness, tingling in extremeties, headache, slurred speech, irritability, unstable movement, personality changes, seizures, DEATH HOW SHOULD I CYCLE INSULIN? Insulin should be cycled so that you have less of a chance of permanently affecting your own body's production of insulin. Even cycling can affect your own production though so be aware and see your doctor regularly. I say 4 weeks on and 4 weeks off as a general rule of thumb with 6 weeks on being the absolute limit in my opinion. ------------------------------------------------------------------------ ---------- This was meant to be a basic introduction to using insulin. I do not condone the use of insulin by non-diabetics nor am I encouraging anyone to use insulin. I am not a doctor and YOU are the only one who can be responsible for making the decision to use insulin. I hope this helps someone to stay safe and think things through before jumping into the unknown. Good luck to all- AD

posted by jcvaughn26

THE SKINNY ON INSULIN There has been increasing popularity, and curiosity, concerning exogenous use of "the most anabolic hormone in the body". This makes it necessary to inform people how to maximise muscle mass acquisition and minimise horrid body fat accumulation when using it. The following is a detailed description of the effects of exogenous insulin use, combined with several other common bodybuilding drugs, from a muscle anabolism and fat catabolism point of view. *WARNING* Morons and bodybuilding novices should not consider insulin use, because it has one of the highest potentials for danger of all bodybuilding drugs. Its' use requires complete discipline and control over ones' environment. Insulin misuse should not be taken lightly because death's from it occur almost weekly. If that doesn't scare you, consider this: it can make you very, VERY, fat. Before we delve in to the insulin alchemy, we should understand why insulin does such a good job of muscle and fat accumulation. Of course insulin is known as "the storage hormone", which means that it stores various macronutrients in different body tissues. Protein storage comes directly from amino acid uptake and protein synthesis in skeletal muscle. This is what we want. Now the fun part. INSULIN AND ANABOLIC STEROIDS Of course when everyone thinks of bodybuilding drugs anabolic steroids (AS) are the first things to come to mind, but how do they work with insulin? VERY WELL! AS decrease insulin induced fat accumulation through a number of ways. One is through creatine synthetase, which is an enzyme that goes crazy after workouts trying to store carbohydrates in the muscles (as glycogen, creatine phosphate etc.). For every gram of carbohydrate stored in muscle, roughly four grams of water go along with it (this is how creatine monohydrate achieves such dramatic results). How does this relate to insulin and AS? Well, the "harder" AS (exemplified by oxymethelone) increase creatine synthetase levels dramatically, giving insulin a place to do its' job and store carbohydrates. Okay, this also counts for a combined anabolic effect, but it prevents insulin from converting any "excess" carbohydrate in to fat (which would subsequently be stored)! AS also decrease levels of the main fat storage enzyme that insulin increases (called lipoprotein lipase). A big effect is through glucocorticoid antagonism, which means that AS indirectly increase insulin sensitivity (as well as act anti-catabolically). This allows insulin to bind to its' receptors more easily and accomplish its' job rather, than converting more macronutrients in to fat. Finally, the demand for nutrients by muscles is so high, in an AS enhanced state, that there is rarely any excess of nutrients to actually be stored as fat! A mere 400 mgs of enanthate didn't allow me to accumulate fat whether I was using insulin or not. From a muscular anabolic perspective, there is a synergistic effect between AS and insulin. This is because they both directly stimulate protein synthesis as well as other mechanisms. One such mechanism involves AS hepatic mediated somatomedin release. Simply put: IGF-1 production in the liver. Again, the more powerful the AS, the more IGF-1 release, with orals having a much greater effect than injectables. Insulin increases the duration of time that IGF-1 is active in the bloodstream, and enhances receptor mediated IGF-1 activity (all through enhancing specific IGF-1 binding proteins). Another great combined effect is that insulin reduces the amount of Sex Hormone Binding Proteins (SHBP) in the blood stream. This allows more AS to be active and do their job of making you grow! Great effects were seen while using 10 units of insulin only three times a week, with AS. For the first few weeks of my next cycle I'm not going off the stuff, and I expect the effects to be scary!

posted by jcvaughn26

CONTINUED FROM ABOVE INSULIN AND THE C/A/E STACK In case you've been living on Mars for the past few years, CAE stands for Caffeine, Aspirin, and Ephedrine. This stack has been shown to synergistically strip off fat, while preserving muscle mass. It is considered here because it is the minimum requirement, while using insulin, to prevent you from looking like the StayPuft marshmallow man. Also of benefit is that it is cheap and easily accessible. Using three times a day helps slow the fat accumulation, but strict dietary control is also necessary. The ephedrine: suppresses appetite, stimulates thermogenesis, and promotes and fat release from cells (beta receptor, and catecholamine, mediated), while the other two components of the stack increase thermogenesis by inhibiting certain enzymes and transmitters that try to slow down the thermic effect. Ultimately the appetite suppression effectiveness of ephedrine wears off, but this is replaced by a greater thermogenic effect (5-deiodinase, or Beta-3, mediated). The CAE stack does nothing for muscle anabolism in a hyper caloric situation, but that's what the insulin is for. INSULIN AND CLENBUTEROL This "soon to be classic" post-cycle stack not only increases muscle mass, but keeps fat off at the same time. Fat loss from clen is legendary for the first two weeks. After that time, the beta-2 receptors that it activates, attenuate (because of the extremely high binding specificity), dropping the fat burning effects to minimal levels. There should still be beta-1 receptor activation (which stimulates fat release from adipocytes) and beta-3 stimulation (the big thermogenic wonders), because they attenuate slower or not at all (respectively) compared to beta-2 receptors. Clen is a much better fat burner than ephedrine, due not only to its' higher receptor specificity, but also due to it's extremely long half life (the exact reason it's not approved for use in humans). This means that the drug is constantly burning fat, especially at night when serum glucose, and insulin, are low. Using aspirin and caffeine might slow the receptor attenuation, or at least increase the thermogenesis while its there (I can certainly attest to this!). Why hasn't anyone done this sooner? Clen, like AS, directly combats the fat storing enzyme that insulin promotes (lipoprotein lipase again) in white fat. However it actually increases this enzymatic activity in brown fat (hence the thermogenesis) and muscle. The latter event could promote muscle anabolism through a similar mechanism to HMB, or at least increases muscular fat storage (merely increasing muscle size). This may not seem significant, but the way that people are going nuts over synthol, you never know! The mechanism of action of clens' muscle building effect is not known, but it appears to be anti-catabolic rather than directly anabolic. It should be noted that this anticatabolism is not beta receptor mediated , and therefore does not attenuate. At any rate, the combined effect of the two drugs can be noticeable muscle gain while keeping fat off for the first two weeks. Can fat accumulation be slowed with this stack continue past this time? I'll let you know! THE SKINNY ON INSULIN: PART II There has been increasing popularity, and curiosity, concerning exogenous use of "the most anabolic hormone in the body". This makes it necessary to inform people how to maximize muscle mass acquisition and minimize nasty body fat accumulation when using it. The following is the second article dealing with the effects of exogenous insulin use, combined with several other bodybuilding drugs and supplements, from a muscle anabolism and fat catabolism point of view. Part I outlined insulin use combined with: anabolic steroids, the C/A/E stack, and clenbuterol. *WARNING* Insulin has one of the highest potentials for danger of all bodybuilding drugs. It shouldn't be screwed around with. INSULIN AND GROWTH HORMONE Growth hormone (GH) is one of the most sought after bodybuilding drugs due to its' legendary abilities to strip off body fat and increase muscle mass. The former is accomplished through direct lipolysis (fat release from adipocytes), which GH does to an incredible degree. Muscle mass acquisition is accomplished through: the direct stimulation of protein synthesis, increasing amino acid uptake by muscle cells, and by greatly stimulating IGF-1 synthesis in the liver. It is this last point that is of interest to us because it is the main anabolic mechanism for GH, and it is also where insulin comes in to play. More than half of GHs' anabolic effect is due to IGF-1 production, but unfortunately this is quite often wasted. This is because IGF-1 has an extremely short half life in the bloodstream, so it usually doesn't reach many target tissues (muscles for our interest) to exert maximum anabolic effect. To rectify this situation, insulin can be used to increase the amount of an IGF-1 binding protein (specifically IGF1-BP3) that actually helps IGF-1 to reach the muscles and exert its' extreme anabolism. Insulin also reduces the amount of "bad" IGF1 BP's, (BP's 2 and 4) that would normally interfere with IGF-1 uptake and use by muscle. To say that there is a synergistic effect between insulin and GH doesn't do the combination justice. It makes me shudder to think of the hundreds of thousands of dollars spent on GH, without using it to the maximum anabolic potential. From a fat loss perspective, GH is incredible. It should directly negate the lipogenic effect of insulin, leaving you with one KICK ASS combination. INSULIN AND THYROID HORMONES With the huge increases in fat mass often accompanying insulin use, it seems like a simple solution to use thyroid hormone. Unfortunately, this doesn't work out very well. The reason is that thyroid hormone (specifically T3 and possibly T4) increases the amount of the "bad" IGF1-BP's mentioned earlier;IGFBP2 and IGFBP4. This may not seem like a big deal if one is not using drugs to stimulate IGF-1 synthesis, but IGF-1 levels are naturally stimulated through acts like stretching, and even natural testosterone/GH increases. All of these things normally accompany workouts (if you know what you're doing), which is the best time to take insulin. So by having all of the free IGF-1 bound by IGFBP3s' evil siblings, much of the anabolic effect of insulin is lost! Since T3 (triiodothyronine) is the main culprit, does that mean that T4 (tetraiodothyronine) can be used with no detrimental effect? NO, because T4 is mostly effective by converting to T3, which leaves you with the same problem. In fact, T4 could very well do the same thing. So if you want to maximize the anabolic effectiveness of insulin while minimizing bodyfat accumulation, use another fat burner and leave the thyroid alone. INSULIN AND CREATINE These compounds may have an anti-synergistic effect on each other, meaning that the combined effect is less than the sum of the individual effects. This possibility exists due to both components' ability to store water in muscle cells. If only a certain amount of water can be stored in the cells through each mechanism of action, then the anti-synergistic condition would exist. Although this condition is unlikely, it is worth mentioning for future experimentation purposes (lab rats know where to contact me). One definite advantage of this combination is that creatine is best absorbed by the muscles when insulin serum levels are high, insuring maximum effectiveness. BTW-if one is not doing something as fundamental as using creatine, there is no way they should be using insulin (so basically insulin use requires creatine use). INSULIN AND HCA Getting straight to the point, unless you are a moron and are eating fat during insulin use, or you have crappy insulin sensitivity, HCA is the second most effective fat gain inhibitor next to clenbuterol (which is only more effective due to its' ridiculously long half life). Hydroxy Citric Acid (HCA) is the main ingredient in Citrimax, and is a bargain in terms of its': relative effectiveness (when using insulin), cost (cheap, cheap, cheap), and availability. It works by inhibiting an enzyme called ATP citrate ly(s)ase (ACL), which basically converts ingested carbs to fat (which insulin promptly stores). This is normally NOT a big deal since ACL levels are normally low in most humans. However, insulin drastically increases ACL levels (which should make sense based on what you now know about insulin) accounting for most of the, responsible use, fat gain associated with insulin use. This is the most exciting find since the discovery of insulin as an anabolic! Using insulin and not gaining fat while gaining muscle? What a concept! Although I don't like to go into the details of use directly, I believe it is warranted here. 500-750mgs HCA should be taken with or within half an hour after the insulin shot. The usually recommended 250mgs is ineffective in dealing with the drastic increase in ACL levels. The HCA is taken with the shot because both start to work on about one half hour, so the HCA can begin to be effective at the same time that insulin is trying to increase ACL levels. This regimen (only 3X500mgs HCA) prevented fat gain during a day when I used 3 separate insulin shots! To make things even better there is a mild glycogen storage property associated with HCA use. Since ingested carbs cannot be converted to, or stored as, fat, they are generally stored (due to insulin) as glycogen in muscle giving the user a mild but noticeable pump (similar to the first day of creatine use). To end this portion of the list, I give HCA my highest recommendation as the number 1 supplement to use with insulin!

posted by jcvaughn26

CONTINUED FROM ABOVE INSULIN AND FLAX SEED OIL Short and sweet. Don't use flax seed oil with insulin, because it is fat and *will* be stored. The fat storage rules totally change when insulin is involved (I even avoid vitamin E capsules because mine are oil based). INSULIN AND CLENBUTEROL UPDATE This may look like an ideal combination at first, but research has shown why my muscle gains with this combo were minimal. Clen reduces insulin sensitivity, which means that insulin will have a much harder time doing its' anabolic job on muscle tissue. In addition to storing amino acids as muscle, insulin also stores carbs in muscle (which gives a very "full" look to the muscles), which reduced insulin sensitivity also hinders. This is also combined with the fact that clen reduces Glut-4 transporters (which allow glucose passage, and subsequent storage, into muscle) in skeletal muscle which probably accounts for clens' ability to reduce muscle glycogen concentration. On a lighter note, the fat burning effects of clen are potentiated by aspirin and caffeine (through personal experience) but still die off after a few weeks. Overall the only time I would recommend this combination occurs when coming off a cycle and every bit of anabolism is needed, otherwise the two drugs have a bad effect (from an anabolic standpoint) on each other SIMPLE TIPS TO MAXIMIZE ANABOLISM AND MINIMIZE FAT GAIN WITH INSULIN USE -USE HCA - use testosterone enhancing compounds to increase hepatic IGF-1 production - only use insulin first thing in the morning or during/after workouts - don't consume *any* fat 2 hours before (due to digestion time) or one hour after (due to induced enzyme activity) insulin use - stretch to locally increase IGF-1 levels - continually eat protein spread over the 4-5 hour duration of insulin activity Finally, my favourite tip from Docroid: (I) use one shot of insulin just before a one hour workout and another shot two hours after the first. This creates synergism between the activity of the two shots by the later shot increasing in activity at the same time as the first shot decreases in activity, giving one a steady high insulin level at the most important time for anabolism! The only time I can say that I have seen dramatic results from insulin use (in terms of muscle anabolism) occurs when I do this "technique". HOWEVER, this is *very* tricky, in terms of serum glucose levels, even for seasoned insulin users. After using for a while, one can get used to the "feel" of insulin, blood sugar crashes, feeding times etc. but things change when one has a high level of insulin for 3-4 hours straight. I've had to eat every hour for three hours during one of my first attempts at this technique, but every two hours some other attempts. This is the only time I don't feel secure with my own insulin use. It's actually a good thing I can now recognize what a blood sugar crash feels like or I'd probably be dead due to this technique. I don't recommend this technique to anyone (and if that's not a big deal to you, just remember who is writing this) but if you feel like using it, make sure that you have had a couple of, (horrible) insulin induced, serum glucose crashes so you can recognize the early warning signs for when you have them (and you *will* have them). THE SKINNY ON INSULIN: PART III *WARNING*: Insulin is not a drug to be taken lightly. It's use can harm or even kill an ignorant user. If you plan on using, educate yourself and at least read the last part of this article. INSULIN AND ANDROSTENDIONE This combo has potential due to the interesting ability of insulin to increase levels of 17B hydroxysteroid dehydrogenase(17B), which is the enzyme that converts andro. into testosterone. If the increase is anything near the 17B levels that women have, this could become the stack for "natural" Ïbodybuilders. Another possible benefit of this stack is the idea that insulin probably exhibits mild anti-aromatase properties. If this occurs to any significant level it could be great in increasing the 17B levels even more! Although I hate to rain on this theory parade, I have to say that I can't notice ANY anti-aromatase activity from insulin(see first update section). Other possible benefits of this stack are shown in the first part of this series under: "INSULIN AND ANABOLIC STEROIDS". Of course any potential similarities with AS would be drastically minimized with andro. It should be noted that the term "natural" is used quite loosely.

posted by jcvaughn26

CONTINUED FROM ABOVE INSULIN AND CAPTOPRIL Captopril is an angiotensin converting enzyme(ACE)inhibitor. Its' medical function is to reduce blood pressure. The reason it is included here is because it can have great effects with insulin and AS. I wouldn't reccomend captopril to anyone unless you are hypertensive or are using AS, because it can drop blood pressure to a sub-normal level. A reason captopril is so great is because it increases endogenous growth hormone levels, which you know can be amazing, assuming you've read last month's article. Another benefit to captopril is its' decrease in protein urea(protein loss in urine). No other drug I'm aware of, including AS, GH, or insulin, does this. This means that there will be more protein for those other anabolic drugs to assimilate! Another great use of captopril is the fat loss effect it has. For me it removes the necessity of HCA while using insulin (with AS). Although I still use one 250mgs of HCA/day just for good measure, I could probably get away witho!ut it despite the extreme carb intake after a workout. On a more esoteric note, long term captopril use actually prevents the formation of new Alpha2 adregenic receptors, which would further potentiate fat loss. Also, water retention is minimized through captopril use, which ties into the blood pressure effects. A potential risk while using captopril with insulin is that both drugs do a good job of making one tired/sleepy. Add in a late night, high intensity workout and you'rer ready for bedtime. One can NOT fall asleep while using insulin or you would experience all of the dangerous side effects associated with its' use. A final warning about captopril is that it increases the retention of potassium which makes hyperkalemia (too much potassium)a possibility. Unexcessive intake of this electrolyte should allow for avoidance of any problems in most people. This stack really doesn't have any problems associated with it, as long as common sense is used. It is merely a matter !of responsibility to point out every potential problem, sim!ply so it can be avoided. It should be noted that beta agonists and even working out increase proteinurea. INSULIN AND ANABOLIC STEROIDS UPDATE I hyped up insulin and AS in the first article in this series and I don't take any of it back. Simply put: this combo rocks! Using these compounds I put on 10lbs in 4days! It wasn't fat or subcutaneous water so it had to be muscle! Okay, it was just intracellular water, but the results are still dramatic to say the least. Three 14IU shots a day keeps my body in a ridiculously powerful state of anabolism. I recommend that 100grams of easily digestible protein be consumed during the 4 hour duration of the drug (while juicing). At this time it can be assumed that every gram will be assimilated. My HCA use is down to every third shot of insulin, and that may be slightly unnecessary. Please note that I am also using captopril which exhibits fat loss characteristics. I have no other big tips to offer, except (I'd) use insulin as much as possible while on a heavy cycle. Since I'm getting gyno while using anti-estrogens, I have to say that the anti-aromatase ability of insuli!n is next to non-existent. I'd like to note that another AS/insulin user was also using GH and still gaining fat, although I don't know what his eating was like. INSULIN AND BETA-AGONIST UPDATE I now realize that the use of beta-andregenic agonists is useless while on insulin. They decrease insulin sensitivity and increase cortisol levels. Their fat loss abilities are overshadowed by the negative effects on insulin and anabolism. HCA should prevent any responsible use fat gain, making use of these compounds all the more futile. The only time I'd recommend clen and insulin is when coming off a cycle(I obviously don't buy the "clen is not anabolic" theory). QUICK INSULIN USE TIP Although nocturnal feedings are effective in keeping positive nitrogen balance, and decreasing the diurnal (daily) morning cortisol rush, they should not be used while using insulin during the day. These nocturnal feedings may prevent insulin sensitivity from improving as much as normal, which would lead to less anabolism and greater fat gain. The use of AS or doing insulin shots only after workouts negate this suggestion.

posted by jcvaughn26

CONTINUED FROM ABOVE STATEMENT ABOUT PERMANENT INSULIN DEPENDANCE This potential side effect has been WAY too hyped by the anti-insulin propogandists. The idea of your own pancreas shutting down insulin production due to exogenous use is silly, and requires massive irresponsible use over extended time periods. Using myself as an example, I've been using insulin for 7 months straight. "WHAT?! Why did my pancreas not explode long ago?" You ask. For a simple reason: responsible use. I think that peoples fear of becoming dependant on insulin stems from minor knowledge about the testosterone feedback loop and AS cycles. Another part of this moronic recipe is peoples'ignorance about their own body and that brilliant bullshit anti-insulin propaganda. Quick lesson. Your body(beta cells of the pancreas)produces insulin in response to increased serum glucose levels, specific amino acids etc. As long as you don't shut this mechanism down from exogenous insulin use for long periods of time there should be no pr!oblems(unless you're ****ed to begin with). This means that you'd have to use insulin for 12 hours a day(3 perfectly spaced out shots)for over three months while insuring that you are not stimulating endogenous insulin production. Only a moron could do this which makes me wonder why it doesn't happen all the time). Another problem could arise if one uses an insulin shot every day at the same time for months on end. For example if one did a shot upon arising for many months, prior to eating. After a while the body would become conditioned(due to external/internal cues) to not produce insulin at that time. [note:I used morning insulin shots for 4 months without adverse effects] This situation could be easily remedied by tapering down the dosage of insulin over a period of weeks (although I hesitate to make the connection with AS). The bottom line is that using insulin before/after workouts for any length of time will not shut down the beta cells for long enough to cause this !problem. Remember that the beta cells are normally shut do!wn for at least 8 hours a day, while sleeping, and this happens for 80 years without adverse effect. INSULIN USE: IS IT WORTH IT? Although I despise the anti-insulin propaganda, which I have contributed to in the past, it does have some merit. Personally I wouldn't care about people dying from insulin use, if only it didn't expose this drug in a negative light. I simply see insulin screwups as somebody sticking shit into their bodies that they know nothing about(meaning: it is on 8 thier 8 head).But in my position I have to wonder why the person tried the stuff in the first place. Lately I've been quite curious about peoples'insulin use because, to be honest, the shit just isn't that great! Don't get me wrong I'd never recommend another AS cycle without it, and you'd have to be a moron to spend $8000. on GH without learning the finer points of insulin use...but there's no reason for people to be using this stuff on a "try it and see" basis. Personally I wouldn't let some guy in an article stop me from trying this normally safe (with responsible use) drug, and I would never try to dis!suade anyone who "has to know" that it is like. But seriously, there's no other reason, for anyone not trying to maximize muscle mass, to use this drug. I don't like it but it's the truth, so I have to report it. For me(the genetic loser of the century), insulin doesn't do much without AS. I will always use it as a training aid, but that's only because I've already gone through the bullshit of planning out my body's reaction to the stuff. I also like the fact that I've come to know my body better than I could have without insulin, but that's only because I've had (too) many sugar crashes to help me feel my serum glucose status. To end this depressing section I have to restate that this is not intended as some "life-saving", anti-insulin propaganda. I'm just stating that insulin doesn't do that much (notable exceptions already mentioned) and certainly doesn't deserve all the hype (good or bad). [I think I'm going to cry now]

posted by jcvaughn26

Description: This description was taken directly from Brian Raupp's Anabolix Research page since this drug is so dangerous and his description is by far the most comprehensive that I have found on the internet. Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscles. In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia. Hypoglycemia occurs when blood glucose levels are too low. It is a commonand potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he understands the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death. Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid will have higher insulin requirements, and therefore, will be able to handle higher dosages. Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete can not purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U-100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin in the abdomen area. To speed up the effect of the insulin, many athletes will inject their dose into the thigh or triceps. Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia. Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during his slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting. Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inject a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. Finally, some athletes like to inject insulin upon waking in the morning. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way. Insulin use can not be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences. One mistake in dosage or diet can be potentially fatal. Effective Dose: 1 IU per 10 - 20 lbs. of body weight Street Price: Can be bought over-the-counter for around $15 - 20 / 10 cc. bottle Humulin-R The Physiological Role of Insulin in the Body: Insulin is a hormone which is manufactured in the pancreas and which has a number of important physiological actions in the body. It is an essential hormone in maintaining the body's blood glucose level so that the brain, muscles, heart and other tissues are adequately supplied with the fuel they require for normal cellular metabolism and normal function. Insulin also plays an essential role in fat and protein metabolism. For example, it promotes transport of amino acids from the bloodstream into muscle and other cells. Within these cells, insulin increases the rate of incorporation of amino acids into protein (amino acids are the building blocks of protein) and reduces protein break down in the body ("catabolism"). These physiological actions probably form the basis of speculation regarding the additional anabolic gains which might be made through the use of exogenously administered insulin.

posted by jcvaughn26

CONTINUED FROM ABOVE Normally, blood glucose and blood insulin levels are not both elevated for any extended period of time as these two chemicals influence each other through a feedback system in the body. In the post-absorptive state, the blood insulin concentration tends to decrease during exercise, allowing the blood glucose to be maintained at or above resting levels and to provide increased energy supplies (fuel) to muscle cells. Following a meal, the blood glucose and amino acid levels rise (the absorptive state) and this triggers an increase in insulin release from the pancreas, driving glucose and amino acids from the blood into cells and maintaining the blood glucose level within a certain physiological (operating) range. Intending users should also be aware that insulin stimulates lipid (fat) synthesis from carbohydrate ("lipogenesis"), decreases fatty acid release from tissues ("lipolysis") and leads to a net increase in total body lipid stores. The development of such increased body fat stores runs counter to the training goals of most body builders, athletes and those seeking to improve their physical appearance. In striving to become bigger, stronger, more competitive or more physically attractive you should also remember that no matter what you do, your genetic make-up will have an influence on what you are able to achieve. It is important to realize that you cannot look exactly like the role model you admire because you have inherited a different set of genes. The Glycemic Index Factor: Scientists have discovered that carbohydrate containing foods can be measured and ranked on the basis of the rate and level of blood glucose increase they cause when eaten. This measurement is called the "Glycemic Index" or "G.I. factor". The rate at which glucose enters the bloodstream affects the insulin response to that food and ultimately affects the rate at which this glucose (fuel) is made available to exercising muscles. (2) Low G.I. foods are those measuring less than 50 on a scale of 1-100. Moderate G.I. foods are those with a reading of 50-70 and high G.I. foods are those measuring 71 or greater on this scale. Pure glucose has a G.I. of 100. Foods which have a high G.I. produce a rapid increase in blood glucose and blood insulin levels. Examples of such high G.I. foods are potatoes, ice cream, many cereals particularly those with a high sugar content, some varieties of rice (e.g. Calrose) and sweets. Foods with an moderate G.I. include some brands of muesli, some varieties of rice, white or brown bread, honey and some cereals. Foods with a low G.I. produce a slower, smaller but more sustained increase in blood glucose levels. Examples of such low G.I. foods are pasta, varieties of high amylose rice, barley, instant noodles, oats, heavy grain breads, lentils, and many fruits such as apples and dried apricots. Low G.I foods are advantageous if consumed at least two hours before an event. This gives time for this food to be emptied from the stomach into the small intestine. Since these foods are digested and absorbed slowly from the gastro-intestinal tract, they continue to provide glucose to muscle cells for a longer period of time than moderate or high G.I. foods, particularly towards the end of an event when muscle glycogen stores may be running low. In this way, low G.I. foods can increase a person's exercise endurance and prolong the time before exhaustion sets in.(2) High G.I. foods, preferably in the form of liquid foods or glucose drinks of approximately 6% in concentration, can enhance endurance during a very strenuous event lasting more than 90 minutes. ("strenuous" being defined as an athlete exercising at more than 65% of their maximum capacity). Some athletes may prefer food rather than liquid replenishment. Miller(2) suggests glucose enriched honey sandwiches, which have a G.I. factor of 75 or jelly beans, which have a G.I. factor of 80. Miller suggests that an athlete who is engaged in a prolonged strenuous event should consume between 30 and 60 grams of carbohydrate per hour during the event. High G.I. foods are also desirable after completing an exhausting sporting or training event when muscle and liver glycogen stores have been depleted, as they provide a rapidly absorbed source of glucose and stimulate insulin release from the pancreas. This insulin in turn stimulates the absorption of glucose into liver and muscle cells and its storage as hepatic and muscle glycogen, optimizing recovery and preparation for the next training or competitive event. It has been shown that greatest benefit can be had if an athlete consumes these high G.I. carbohydrate foods as soon as possible after an event, preferably within an hour or less. It is further recommended that a high carbohydrate intake be maintained during the next 24 hours. Miller suggests eating at least one gram of carbohydrate per kilogram body weight each 2 hours after prolonged heavy exercise and at least 10 grams of high G.I. carbohydrate per kilogram body weight over the 24 hour period following this exercise. For these reasons, an athlete who needs to maintain a high level of activity and performance on consecutive days or more extended periods of time should eat large amounts of high G.I. foods. However, a reasonable quantity of low G.I. carbohydrate food should be consumed before an event in order to improve endurance. A Natural Method of Maintaining an Elevated Blood Insulin Level: Noting the hypothesis that an elevated blood insulin level may be of some advantage to bodybuilders, Fahey and his colleagues (1993) undertook an experiment in which they fed athletes a liquid meal of "Metabolol", which consisted of 13.0 g protein, 31.9 g carbohydrate and 2.6 g fat per 100 ml and provided 825 kJ of energy. These researchers demonstrated that it is possible with such intermittent feeding during intense weight training to maintain a person's blood glucose at or above resting levels and at the same time, significantly increase insulin levels for the duration of the workout. This suggests a potentially effective and safe non-drug method for achieving a sustained elevation of blood insulin levels. The authors of this research commented that "theoretically, this could provide a biochemical environment conducive to accelerating the rate of muscle hypertrophy and inhibiting protein degradation." However, the writer knows of no scientific studies which support this theory. It is also relevant to note that muscle repair and growth begins in the hours and days following heavy exercise. It is doubtful that the use of insulin just prior to a workout will have any anabolic effects over and above natural processes, at this time. However, use of insulin prior to a workout will certainly expose you to much greater risk of serious harm. If you believe it is beneficial to have a higher insulin blood level during workouts, use the natural method outlined here. Level of Risk Associated with Insulin Use: The use of all drugs carries some risk along with potential or perceived benefits, whether used for legitimate medical reasons or for other purposes. Insulin carries some risk even when used by an insulin dependent diabetic, as demonstrated by the observation that some diabetics run into difficulties with their treatment from time to time and often require assistance to restabilize their medical condition and insulin requirements. If used by a healthy non diabetic person in whom there is no natural deficiency in insulin production or reduced insulin sensitivity and in the absence of medical advice and monitoring, the risks may be substantially increased. The major risk associated with insulin is a physical state known as hypoglycemia or "low blood sugar". This occurs when the level of glucose in the blood falls below a certain level required for normal body function. If the blood glucose level is substantially reduced below this normal level and if this is not quickly corrected, there is a risk of disorientation, collapse, coma, permanent brain damage and even death. Exercise and reduced food intake decreases the body's need for insulin and increases the risk of hypoglycemia associated with non-medical use of insulin.

posted by jcvaughn26

Continued from above It is difficult to provide a quantitative estimate of risk for any drug but on a scale of risk in relation to other non-medical and unsanctioned drug use, the use of insulin in this manner would rank towards the higher end of the scale. If zero equals "no risk" of harm to a person's health and ten equals "extreme risk", the use of anabolic steroids in a non-medical context might rate towards the middle of the scale of risk (particularly in the medium to long term) whilst insulin would rate higher. This level of risk associated with insulin use will depend on a number of factors: Whether the person is a diabetic or not: non-diabetics and lean healthy people are more sensitive to the blood glucose lowering effects of insulin than diabetics; Type of insulin: short acting insulin preparations are considerably safer than long acting preparations because with short acting types, it is much easier to avoid hypoglycemia with adequate food intake. With the non-medical use of longer acting insulin preparations, a person is at real risk of experiencing hypoglycemia late in the day, particularly in between meals, during or after exercise and when asleep. Regardless of this advice, some people are in reality using a mixture of short and long acting insulin preparations and exposing themselves to unnecessary increased risk. Food intake: the type and timing of food consumed, its glycemic index (the glucose elevating effect) and the amount consumed, Body weight, Timing of insulin administration in relation to food intake and exercise. Individual variation: two different people can respond in a very different way to a given dose of insulin, even if they are of a similar height, weight and other personal characteristics. The fact that a certain dose does not seem to cause a problem for one person does not mean this will be so for another. In addition, the response to insulin will also vary greatly within any one individual over time, according to changes in one or more of the above noted factors. 5-10 Units of a short acting preparation may have little or no observable impact on someone who eats a meal soon before or after but this dose could cause hypoglycemia and collapse in a person who has not consumed adequate food in close proximity to the time when the insulin begins to take effect (insulin starts to take effect within 5-10 minutes if injected by intra-muscular route and in 30-60 minutes if injected by subcutaneous route). Foods with a high glycemic index will maintain the blood glucose level for a short period of time, perhaps an hour or so whilst those with a low glycemic index will provide for more sustained glucose levels. Risk Reduction Advice: Given the risks of using insulin for non medical purposes, the best advice one can give is not use it in this way. Even the body building magazines such as "Muscle Media 2000" advise: "If you're thinking about using insulin, think twice - it's really risky!"(3) However, if you are not persuaded by this advice and are determined to pursue its use in the hope of achieving some additional anabolic or other gains, you should take the following precautions: level during workouts by consuming glucose containing fluids at intervals during exercise. These fluids may have a protein sparing effect and at the same time, will help maintain keep your blood glucose and blood insulin levels. However, if you decide to use insulin, you should consider the following advice: Always use insulin in the presence of someone else who knows about and understands the exact risks of using insulin in this manner, so they are able to act quickly and appropriately should something go wrong; Always use a sterile needle and syringe every time and a clean injecting technique (e.g. don't touch the needle or the skin where you are going to inject, with your fingers and don't breathe on or cough over the injection site before or after injecting.) Be aware that 1.0 ml of insulin contains one hundred International Units (100 IU), 0.1 ml of insulin contains ten (10) IU and 0.01 ml contains one (1.0) IU. So take care in measuring out your insulin, It is very concentrated! Note that 0.01 ml is the volume contained in the space between the smallest graduated markings on a 1.0 ml Terumo diabetic syringe; Inject by the subcutaneous route (injecting just under the skin and preferably in the abdominal area or outer part of the upper thigh), not intramuscularly or intravenously as using the latter routes can lead to a rapid rise in blood insulin level and a sudden hypoglycemic episode; Alternate your injection sites in order to minimize tissue damage ("lipoatrophy" or "lipohypertrophy"; Always use a short acting, "regular" insulin (e.g. Actrapid, Insulin Neutral, Humulin R, Hypurin Neutral) rather than a longer acting insulin preparation (e.g. Semilente, Lente or Ultralente); Use a human insulin rather than an animal insulin preparation if possible (there is little animal insulin available now); Start with no more than 5 IU (0.05 ml) of this short acting/ regular insulin preparation and increase the dose gradually over a period of one week, to a dose no higher than 20 IU (0.20 ml) per day. Doses above this will expose you to progressively greater risk and most body builders who use insulin believe there is no advantage in taking doses higher than this. Anecdotal evidence amongst bodybuilders suggests increased doses leads to excess bodyfat accumulation. The writer would caution against users falling into the trap of thinking: "If 20 units is good, 40 units will be twice as good" or "Joe says he injected 20 units and it didn't affect him, so it will be safe for me to inject 30 or 40 units". All drugs have a therapeutic dose range and above this, may be toxic or even lethal. If you are not diabetic, your body does not require additional insulin and there is no therapeutic range for you. In addition, people are different and often respond differently to drugs. An individual may also respond differently to the same drug in the same dose at different times, depending on a wide range of factors such as their general health, alcohol or other drugs taken, food eaten, exercise undertaken before, during or after drug administration and so on.

posted by jcvaughn26

CONTINUED FROM ABOVE Don't use a medium or long acting insulin in the middle or latter part of the day, as you may very well experience a hypoglycemic attack whilst you are asleep. If this happens, neither you nor anyone else will be aware of or able to respond to your urgent need for glucose, in order to prevent possible serious harm. Dietary Guidelines: Close attention to diet is extremely important in people using insulin, whether this is for legitimate medical purposes or for other reasons. You can reduce your risk by consuming an adequate amount and mixture of high and low G.I. carbohydrate foods and drinks immediately after using insulin and at regular intervals (every 2-3 hours) throughout the day. High G.I. carbohydrates (e.g. sweets, soft drinks and ice-cream) will raise your blood sugar quickly and prevent early hypoglycemia. Low G.I. carbohydrates (e.g. white pasta, high amylose rice, softened whole grain breads and instant noodles) are metabolized more slowly and will keep your blood glucose level up over a more extended period of time, when the medium acting insulin preparations begin to take effect; 55-65% of your total daily energy intake should be in the form of carbohydrates, 15-20% as protein and ~20% as fat. You should seek advice from a dietitian about your daily requirements but most heavy training athletes need to consume between 3,000 and 5,500 Calories per day (depending on the sport and level of training) and between 450 and 800 grams of carbohydrate each day. If you are a body builder who weighs 100 kg and your total energy requirements are calculated to be 4,000 calories/ day, you should aim to eat approximately 570 grams of carbohydrate each day. If your total energy requirements are calculated to be 5,000 calories/ day, you should aim to eat approximately 720 grams of carbohydrate each day. Divide up your calculated total daily carbohydrate requirements over the course of your waking hours and consume frequent carbohydrate meals throughout the day. For example, if you require 4,000 calories per day, you might eat six meals of 650-700 Calories at 2-3 hour intervals. This would mean eating approximately 90-100 grams of carbohydrate each meal, which for example you will obtain from 7 slices of bread alone or 4-5 slices of bread with 1 ½ tablespoons of honey or 500 ml of Sustagen or 3 slices of bread eaten with a 450 gram can of baked beans. You can refer to the attached food tables to work out your own requirements according to your own food preferences. You will need to choose a mixture foods from this table with a high, medium or low G.I., according to the nature and level of the training you are doing. Once again, the writer would strongly recommend that you consult a dietitian who has an interest and experience in sports nutrition, in order to assist you design a dietary program which is best suited to your training goals and needs and to your food preferences. It is equally important that you find a dietitian with whom you feel comfortable telling about your insulin or other performance enhancing substance use, as their advice may otherwise be less than useful to you. If your dietitian does not know about and does not take such substance use into account, their advice may even add to the dangers associated with this substance use. Always have a source of glucose or other high G.I. food ready at hand, in case you should begin to experience the symptoms of hypoglycemia. If this does occur, you should take this glucose or food without delay. You should eat or drink 15-20 grams of carbohydrate to begin with, which is contained in ~ 2 slices of white or brown bread, two glasses of milk, a half glass of soft drink, a tablespoon of honey or six jelly beans. Other examples of glucose or other high Glycemic index carbohydrate preparations which you can use include: glucose tablets, glucose powder mixed in a small volume of water, barley sugar, or other sweets or if these are not immediately available, a sugar containing cordial, soft drink or plain sugar dissolved in water. This should be followed by an adequate low Glycemic index carbohydrate meal to prevent further hypoglycemia since the insulin levels are likely to remain high for some hours after the high Glycemic index carbohydrates are used up (metabolized) in the body. The Crucial Role of the Friend or Peer Observer: If you are going to use insulin, it is essential that you have a friend or peer observer remain with you in case you experience problems. This person really needs to be with you for the whole time while the insulin preparation used is working. Be aware that the risk of hypoglycemia occurs not at the time of insulin injection but rather, when the insulin starts to take effect. The risk will be greatest when your insulin blood level nears or reaches its highest level, usually 30-60 minutes afterwards if a short acting insulin preparation is used (by subcutaneous injection) and up to 20 hours later if a long acting insulin is used. Consider giving this paper to the person who is going to be with you when you use insulin, so they are aware of the things to look out for and what to do if you should experience a hypoglycemic reaction. The following instructions are for a peer observer or other person who may find you experiencing difficulty as a result of overdosing on insulin or any other drug or combination of drugs: Instructions for the Peer Observer Assisting an Insulin User: If the person who has used insulin states that they are beginning to feel any of the following symptoms: faintness, dizziness, thirst, hunger, nausea, weakness, sweating, or if you observe that they have become: confused, disorientated, sweaty, drowsy, you should immediately give them glucose or a sugar containing drink or food as mentioned above. However, you should not try to give a person food or fluids if they are so drowsy that they are unable to swallow it, since they will be at risk of accidentally breathing in (aspirating) this food or fluid. If they cannot readily respond to your questions or your commands, you should assume they are unable to swallow anything safely. If the person loses consciousness, you should place them in either a "lateral" or "coma" position, tilting the head fully back and jaw forward, in order to ensure an open airway and protect them from possible aspiration. Keep them in this position while medical assistance is being sought. You should then immediately call an ambulance by dialing "911", to get them to a hospital without any delay whatsoever. When the ambulance arrives, you should tell the ambulance officers exactly what the person has taken and what you have observed so the correct treatment can be provided promptly. This is essential as the person's life may be at stake. Severe hypoglycemia or a combination of alcohol and other drugs, particularly drugs which suppress the central nervous system, can cause a person to stop breathing and their heart to stop beating. Remember, it only takes a few minutes for someone to suffer permanent brain damage or to die, once they stop breathing. There are several common signs which may be apparent in someone who has overdosed from one or a combination of drugs. These include: very slow or shallow breathing or no breathing at all (listen close to the person's mouth and nose for breath sounds and look for movement of their chest wall); snoring or gurgling breathing in someone who is asleep; blue lips and fingernails (caused by lack of oxygen); no response to shaking, calling their name or pain (try pinching their earlobe and pressing down hard on one of their fingernails with a pen); very slow, faint pulse or no pulse at all. What To Do in the Event of an Overdose: stay calm; squeeze earlobe/ press on fingernail of person in an effort to arouse them; if person responds, try to walk them around; if no response, check person's breathing and pulse; if unconscious but breathing, place in lateral or coma position; call an ambulance by dialing 911, they will give you advice on what to do, which might include: if there is a pulse but the person is not breathing, start artificial respiration, otherwise known as Expired Airways Resuscitation (EAR), without delay; if no pulse, start cardio-pulmonary resuscitation (CPR); stay with the person, continuing to administer artificial respiration or CPR until the ambulance arrives. Keep them in the lateral or coma position if they are breathing on their own; tell the ambulance officers exactly what they may have taken and what you have observed. The writer would like to emphasize once more that this paper should in no way be construed as an encouragement to people to use insulin in an effort to increase muscle mass, sports performance or appearance. Rather, it represents a pragmatic attempt at providing harm reduction advice to people who choose to take the risk of using insulin in this way, despite their knowledge of those risks

posted by jcvaughn26

INSULIN. FACT AND FICTION Author Unknown It is without doubt that insulin has made an impact on modern Bodybuilding, in fact it would be fair to say that it is one of most important weapons in an advanced bodybuilder's chemical arsenal. A lot of confusing information is being circulated out there and because of all this misinformation mistakes are being made, it is my intent to help you guys out and maybe show you some of the practical benefits of insulin, as well as some of the REAL dangers of this most powerful of all muscle builders. Insulin is kind of my pet drug and many of you who have seen some of my posts know this (as well as those who go to theuderground chat room on the undernet.) First off Insulin can be dangerous and it can make you fat, if you do it wrong, but do it right and you will experience a level of growth that will parallel your first cycle. First off it may be of some use to understand what insulin does in the body (this info comes courtesy of Novo Nordisk, one of the companies that produce insulin, in this case Actrapid,Protophane, Mixtard, Ultratard and combination mixes of them. I was doing a school project okay?) In short its actions depends on what type of nutrient we are discussing, its actions differ from proteins to carbs to fats. for instance with proteins and fats it promotes the uptake of them into the respective tissue's (i.e. its anabolic, I know you guys know what that is) and its stops the respective tissues from breaking down (catabolic, the bad stuff), this is where the idea of insulin making you fat comes to life.(usually by the pseudo-intellectual's who have never actually done even one jab in their lives) I'll qualify this later as being a load of dumb ass shit, and ill show you how to avoid getting fat. With carb's the action's are slightly different, in that it still gets the nutrient back into the muscle (i.e. glycogen storage) ut in regards to the catabolism of the stored glycogen it for some reason it increases use of glycogen. So basically Insulin makes everything get bigger faster because it forces whatever is being transported faster. Where to get it and what you will need? Okay I suppose I have a bit of an advantage over some of you guys in that Insulin is OTC ere where I'am, but I understand there a few states in the U.S. which sell insulin, either way its still the same.........think about this Mr dear old Pharmacist has a guy in front of him, who is normally dressed(note no baggys and beltbags) looks respectable and is saying that he is a diabetic, he has a) dropped his bottle of Actrapid, b)is out of town, he has his needles and isn't some junkie looking to score some pins, and now he needs a new 10ml bottle (which is apparently an emergency supply), he knows what he is talking about, he knows his dosage etc. etc., its at this point he is probably going to go and get out his little emergency supply pad and write out his own emergency prescription which he has the ability to do. (this worked a while ago for some friends of mine who went and brought 10 bottles of Anapolon 50, from various chemists around town) Now to score the insulin there are two other not so advisable methods but I have done both they are * grease the palm of the pharmacist, hich does work if you are desperate * or get a girl who works in a pharmacy (hee hee hee) Okay you know now how to do it but what are you getting? you want a 10 ml bottle of fast acting insulin, these are nine times out ten going to be either Actrapid or Humilin-R, i have used both of these and they are very much the same. There are animal versions but seeing as its so much easier to get the human version I dont use it so I cant say too much on it either than apparently because it is slightly different than human insulin. Now you really want a 10 ml bottle, but the pharmacist likes to help you out by asking whether or not youd prefer a 3 ml bottle, for the most part these are small and dont last long and it means you have just gone into an pharmacy that you wont be able to use again just for three ml's.Now he needles could be tougher but most places let you get pins without a script for anything bigger than a 22 gauge (again im lucky but then im just boasting), okay now unlike most pins Insulin needles are great as you can use them more than once (one guy i know has used one for the last four months straight) I usually use one per week, by the end of that week its time to get a new one as the pin is a little blunt. They come in a packet of ten and im not sure of the U.S.cost price but they should be about 15-20 cents per pin, now the pins are pretty much all standardised for 100 unit per ml insulin which is the standard concentration you will get, and you can get pins that hold 30 units, 50 units and100 units, I recommend the 30 unit pins as the gradients are easier to see and you can be more exact (especially when you are using insulin to get into ketosis). As for the size of the pins they will either be 27 gauge, 28 gauge and 29 gauge, and they come in long and short length (buy long if you decide to intra muscular jabs and shorts if you are doing subcutaneous jabs) There is a whole market built up abound that of the diabetic sufferer, alot of this assistance gear is nice but it is superfluous to your needs, all you will need is a ten ml bottle of fast acting and ten pins . Anything eels you will just kick yourself for buying as you wont use it. Where to store it? Now hen you get it home you should look for something to store it in as the bottle is pretty weak and could very easily smash if its not protected (been there done that). The best place to put it is the fridge, but for some of you this may not be the best idea with regards to parents or spouses, so it is okay to just leave it in a dark area like you sock drawer or in another cool, dark area. If it is left in an environment over 25 degrees Celsius it will slowly begin to degrade in potency and you will just have to through it away, if it gets warm, its gone. How to do the jab? I aint going to tell you guys how to jab, shit if you dont know by now then you aint ever oing to know. Basically the best sites are in the upper leg and stomach for subcutaneous (sub c) shots, make sure the needle goes in on a perpendicular to the skin surface or else the shot does tend to pinch, but done properly you will not even feel the shot. When doing a sub c shot you should pinch a skinfold (note when you are leaner and this gets harder you will actually notice the effects faster as it does not have as much fat to diffuse through) and jab into that flab you have between your fingers Intra-muscular (i.m.) shots should be done on your delts or quads, dont worry about hitting nerves cause even if you do its unlikely that you will actually do much damage with such a small pin, and you ll be lucky to get that deep nto the muscle, unless you have a real growth problem. How much should I take? Before i go any further this is the section that lead me to do this, i had a call from a friend adn he had his bottle of insulin in front of him and he wanted to hit the shit so he asked "how many ml's do i use?", let me set this straight if anyone usd a ml it is highly unlikely they could eat enough glucose to stop themselves dying. This is what I mean by idiot's for the most part are the ones that make insulin dangerous. Okay now for the good stuff that should get me a flames, i dont beleive in high maounts of insulin, you need 8-10 units per anymore is just a waste and will start to make you fat. now i know there have beeen mentions of 20+ units per shot and i alos haveread that "article" at t-mag with bio as the subject, i havent spoken to bio about that in specific, but he may be doing high amounts of nsulin each meal but I cant confirm (after talking with bio i usually cant confirm much but thats another story)

posted by jcvaughn26

CONTINUED FROM ABOVE I have two ways of doing insulin, dieting and growing. When iam dieting i of course do my orning cardio session, and find that using insulin after the cardio helps me keep anti-catabolic, especially as i dont eat before i do my cardio. A lot of people suggest doing a shot of insulin in the morning as your insulin sensitivity is low form not eating ogver night, I can see the logic in this and at least it has a sense of science that doesnt exsist behind a lot of other cycle theories. But for the most part I leave the morning shot for when I am dieting, my other method for when Iam growing ( i dont really bulk up as such) is to do 10 units in my delt before my workout, i do this to quickly boost the level of the enzyme nsulinase for my workout and then post workout i do another 10 units in my delt or whereever (all the gym staff know what iam doing they take the piss out of me in fact for going into the toilets all the time) this second shot is to help me with my post workout nutrient load, now those of you are on to it well how the hell do you stop yourself from going hypoglycemic mid-set of your workout and killing yourself in the process? Your gym like mine stocks carb drinks just sip on one of those all the way through the workout (again something else my gym staff love me to see me buying, they think thats funny too. They are a funny lot at my gym) and in fact youll find that drinking carbs in your wokout even without insulin will help our recovery as well as helping you stay anti catabolic (good god was that a supplement tip ? from me?). This schedule is the best that i have ever used and definitley helps you put on muscle. Now for your first dosage many say to slowly build up form 5 units, my feeling this is a load of crap even if you are sensitive a little to going hypoglycemic just go and eat something, hell youre supposed to be a bodybuilder, eating is what you do ( ther is a saying in a book " we all go into the gym to lift more each time, but how many of us try and eat more each time we sit at the table" as absolutely no need for that but i just put it in cause its my article) so yeah dont waste time with low unit dosages just start at about 8-10 and just go ith it. Insulin does have its dangers but for the most part it is when idiots use drugs that the drug becomes dangerous. What should i use with it Duh! gear? sorry but let me say this, insulin use without something from the anabolic family is a waste and the more androgenic the better, for a full run down go to www.qfac.com and read the old dirty dieting issue there. but basically the best steroids are your heavy hitters like suspesnsion, prop or some form of test, which ever is your fravourite, Parabolan is of course the best gear to go with (or fina for that matter) both have the benefit that they are very very androgenic, which insulin thrives in (insulin is primarily an anabolic agent and for maximum growth you want to have a good ratio of andrgenic to anabolics to get a full synergistic enviroinment). For some reason I'm a big fan of stanozolol and insulin and i elieve this may have something to do with winstrol being DHT derived in some form, but thats me. Ther may be some point to using insulin post cycle along with clomid as to keep a decent level of testosterone in the system for it to have an effect, but i tend to beleive that without the gear you will get fat big time. Okay of course there is creatine (oh my god that two supplememt tips!!) along with glutamine, both of which insulin helps to load ( **** phospahgen i've got the real deal here , billy boy). Man when i went on these two togethor , i outstripped my record for weight gain in a week (and now as im typing this i realize how long it has been since i loaded on creatine, YAHOO!!) Nutritional Requirements? I could call this insulin and how no to get fat, because that is what you all want, ad it can be done. But it is true that insulin can make you fat and this is where people will go bullshit and ill get another few hundred flames but oh well, all i know is that i stay lean and so do my friends that use these ideas. First of all dont get too high in dosages, the more insulin the more efficently the conversion of circulating fat to stored fat is, so its a case of finding a zone that is not ineffective but isnt overkill, for most people this will be around 8-10 units per shot. Secondly do not eat fat for an hour and half before your first insulin jab and for two hours after you last i.m. jab ( this is one of the reasones i reccomend the i.m shots otherwise you will be waiting for about four hours fron a sub c injection, before you can eat any ignificant amounts of fat. Now im not talking eat no fat, just lower fat. Another common reason for getting fat is using long acting, as i dont know anyone that eats good in the off season, so i cant see people eating low fat all day. Im not saying its impossible to get fat on insulin, its just that if you can do this it wont be the insulin making you fat. As for specific carb ratio's its generally accepted that you will need a minimum of 5 grams of carb's per unit of insulin, but that is a minimum and would be a guide if you were on a reduced carb diet otherwise eat carbs, and as much as you can After a workout, combined with the insulin our body is ready to store nutrients like crazy. It is a good idea to learn the glycemic index, simply beacuse of the fact that some carbs enter into the bloodstream where the insulin is waiting, if the carbs you eat are hi glycemic they will enter very quickly and get soaked up by the insulin, deposited and thenthe insulin will be active still while all the carbs have been spet, this is why Gatorade alone is not a good idea. It is generally a good idea that if you are free to eat what you want, then you should include a mix of fast, medium and slow carbs (high or low glycmeic index). type in Glycemic Index at most search engines and you will get a list of sites that will have this information for you, FYI ice cream has a lower glycemic index than rice!! It is of course a good idea to get some protein in, as your body is now in a full on desire for any and all nutreints, but then the last thing that anyone should have on this board is a protein deficency so I wont insult you by telling you how to eat Will i keep my gains? For the most part, yes. The major benefit over steroids that insulin has, is that if there are receptors that will down-grade, as well as natural productions to shut down, it would, one, take a long time, and two, you would have to be doing long acting insulin, and never giving your body a chance to go withot artificial insulin so your body stops its own production, this is another reason why fast acting is just so much better. The only other way is to be doing frequent fast acting doses, at a high dosage without a break every 6 -8 weeks. I personally know one guy who was doing one shot a day of fast acting for a year and suffered no problems at all, except a lack of desire to sweet foods. What are the dangers? Throughout this i have not mentioned the dangers and while they are not trivial, they are verstated, yes it can kill you, yes you can go into a hypoglycemic coma and theoretically yes it is possible to permanantly stop your bodies natural propduction, but this will only happen with irresponsible use of insulin If you use higher doses you increase the risk of going hypoglycemic, so be safe and go low and get the same benefits If you fail to get a good mix of carbs and you fall asleep because you are tired then you risk going hypo in the night ( i do sleep on insulin but i have usually eaten like a pig, im a big pasta fan) If you dont take a break every 6-8 weeks while employing high doses and frequent dosing then again you may running a risk of permanant blood sugar deficencies But for the most part if you keep insulin asic and are able to eat well then insulin will be the biggest asste sine your first oil shot

posted by jcvaughn26

INTERVIEW WITH PRO I came across this article over at www.nuclearnutrition.com My buddy Trevor wrote it..Pretty interesting stuff. Sli WHAT CAUSED THE HUGE SIZE GAINS MADE BY SEASONED PROS OVER THE PAST 5-6 YEARS?? A CANDID INTERVIEW WITH A TOP I.F.B.B. COMPETITOR INTERVIEWS ARE A DIME A DOZEN AND CAN GO ONE OF 2 WAYS. THEY ARE EITHER COMPLETELY ****ING BORING WHICH IS THE KIND YOU READ IN THE MAGAZINES.....OR THEY ARE COMPLETELY FABRICATED, LIKE THE KIND YOU SEE ON OTHER BODYBUILDING WEBSITES. THIS INTERVIEW REPRESENTS NEITHER. THE NAME OF THE INDIVIDUAL HAS BEEN KEPT ANONYMOUS DUE TO CONTRACTUAL OBLIGATIONS. WITH THAT BEING SAID, WHAT IS TO FOLLOW IS A MOST INFORMATIVE AND EDUCATIONAL INTERVIEW ON ONE PARTICULAR TOPIC: WHAT WAS THE CAUSE OF THE 20-30LB BODYWEIGHT JUMPS FROM 1994-PRESENT. I MEAN LETS FACE IT, NASSER EL SONBATY WAS AN AVERAGE PRO UNTIL 1995 AND RONNIE COLEMAN WAS A 2ND OR 3RD TIER ATHLETE UP UNTIL 1997, JEAN PIERRE FUX GAINED 40 LBS OF TISSUE IN A YEAR AND A HALF, CHRIS CORMIER HAS GONE FROM AVERAGE TO TOP 3, HELL EVEN DORIAN WENT FROM 230LBS TO 260LBS SEEMINGLY OVERNIGHT. ALL OF THESE MEN HAVE HAD LOTS OF EXPERIENCE WITH STEROIDS AND G.H. SO THERE HAD TO BE ANOTHER FACTOR. AT FIRST IT WAS THOUGHT IGF-1 WAS RESPONSIBLE, BUT THIS PROVED TO BE A RATHER INEFFECTIVE COMPOUND. SO WHAT WAS IT? WELL LET'S BEGIN THE INTERVIEW. THIS QUESTION HAS BEEN ON EVERYONE'S MIND SINCE THE EMERGENCE OF 280-290LB BODYBUILDERS FROM SEEMINGLY OUT OF NO-WHERE. I ALWAYS THOUGHT IT MUST HAVE BEEN THE EMERGENCE OF IGF-1, BUT THEN AFTER RESEARCHING SOME THINGS, I FOUND OUT THAT IGF-1 IS A SHIT DRUG AND DOESN'T DO MUCH. WHAT GIVES? I N S U L I N! THAT'S WHAT GIVES! I'VE KNOWN A LOT OF THESE GUYS FOR A WHILE NOW AND I CAN UNEQUIVOCALLY TELL YOU THAT IT IS THE RESULT OF INSULIN THAT THESE HUGE LEAPS HAVE BEEN MADE. INSULIN? IF THAT IS THE CASE, THEN HOW COME SO MANY PEOPLE CLAIM IT WILL MAKE YOU FAT BECAUSE IT CAN MAKE YOU FACT IF YOU DO NOT KNOW WHAT YOU ARE DOING AND DO NOT USE THE RIGHT TYPE. CAN YOU EXPLAIN HOW TO USE IT SO ONE WOULD NOT GET FAT. ACTUALLY IT'S QUITE SIMPLY. YOU SEE THERE ARE DIFFERENT TYPES OF INSULIN L, N, R , AND HUMALOG. THE DIFFERENCE IS IN THE ACTING TIMES. L LASTS IN THE SYSTEM FOR AROUND 24HOURS PEAKING SEVERAL TIMES THROUGHOUT THE DAY AND TAKES 2 HOURS TO BEGIN TO WORK, N IS MEDIUM IN ITS ACTING TIME LASTING AROUND 12 HOURS AND R IS THE QUICKEST OF THESE THREE, LASTING FOR ABOUT 6 HOURS AND HITTING THE SYSTEM IN ABOUT 30-45 MINUTES. HUMALOG IS NEWER AND ACTUALLY BEGINS WORKING IN 5-15 MINUTES AND LASTS FOR 4 HOURS ONCE YOU UNDERSTAND THIS, YOU CAN USE INSULIN TO YOUR ADVANTAGE. WITH ALL INSULIN YOU NEED TO HAVE GLUCOSE PRESENT IN THE BLOOD STREAM SO IT CAN HAVE SOMETHING TO ACT ON AND TRANSPORT IT INTO THE CELLS. THE POPULAR RULE OF THUMB OF 10-15 GRAMS OF GLUCOSE/CARBS PER I.U. OF INSULIN WAS SOMETHING THAT I ACTUALLY CAME UP WITH. PLEASE DON'T THINK I AM BEING ARROGANT, IT'S JUST THAT I WAS DOING A LOT OF RESEARCH ON INSULIN IN THE EARLY 90'S AND IT IS DIRECTLY AND INDIRECTLY DUE TO THAT RESEARCH THAT INSULIN HAS BECOME A POPULAR TOOL IN THE BODYBUILDERS ARSENAL. MANY PEOPLE HAVE CONTACTED ME ON HOW TO USE INSULIN. NOW WITH INSULIN YOU HAVE TO REMEMBER THAT IT IS AN INDISCRIMINANT CARRIER WHICH IS BOTH GOOD AND BAD. GOOD BECAUSE ALONG WITH THE TRANSPORTING OF GLUCOSE, IT WILL ALSO TRANSPORT AMINO ACIDS INTO THE MUSCLE CELLS. BAD BECAUSE IF THERE IS A LOT OF FAT PRESENT, IT WILL SHOVE THAT INTO THE CELLS AS WELL AND THIS IS WHY YOU GET FAT FROM INSULIN. IF YOU USE A LONG ACTING INSULIN THAT PEAKS SEVERAL TIMES THROUGHOUT THE DAY, IT IS IMPERATIVE THAT YOU EAT A CARB AND PROTEIN MEAL EVERY 2 HOURS TO INSURE THAT WHEN IT PEAKS, YOU HAVE A NUTRIENT POOL AVAILABLE FOR IT TO WORK ON. IF YOU TOOK A SHOT OF INSULIN IN THE MORNING AND IT WAS LONG ACTING, IF YOU EAT A PIZZA AT 8:00PM, THE FAT WILL GET TRANSPORTED INTO THE CELLS AND YOU WILL GET FAT. THE WAY AROUND THIS IS TO 1. KEEP DIETARY FAT TO A MINIMUM ALL THE TIME OR 2. USE A FASTER ACTING INSULIN. FOR ME--EVEN THOUGH I ALWAYS EAT LESS THAN 30GRAMS OF FAT PER DAY--THE ANSWER SHOULD BE 2. THE REASON FOR THIS LIES IN THE FACT THAT YOU CAN CONTROL IT MUCH BETTER IF YOU KNOW THAT IT IS HITTING IN 15-20MINUTES AND WILL BE OUT OF THE SYSTEM IN 4 HOURS OR LESS. ALL OF THE INCIDENTS OF PEOPLE FAINTING