Proviron. A must with t3?

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posted by AMERFOOTBALL

Found this on another board.

http://jcem.endojournals.org/cgi/content/abstract/66/4/740

looks like t3 increases shbg, which would leave you with less free test regardless of cycle. sounds like it would be a good idea to use proviron with any cycle that includes t3. Proviron works by binding to the shbg thus freeing up more test...

posted by illsniggles

link dosen't work

posted by AMERFOOTBALL

FIXED IT. oops

posted by brsett

Hmm, I'm new to all this, but . . . I think you take T3 (or T4) to keep your thyroid levels normal while your natural production is shut down (due to dieting). If you're just trying to keep your thyroid in the normal/optimal range, will it really cause the SGHB shutdown? Hard for me to understand with all the unfamiliar acronyms.

posted by AMERFOOTBALL

T3 is thyroid hormone. it is taken while cutting to increase metabolism. T3 apparently also has the effect of increasing Sex Hormone Binding Globin, which takes up approx 50% of your testosterone. Proviron increases free test by binding to the SHBG. Im not sure at what dose of T3 does the increase in SHBG occur, but to get the most out of your cycle, Proviron would be a great addition. Even if your cycle does not include t3, proviron is still a good addition.

posted by president_fad

you can take nettle root too, its a natural form.

posted by brsett

Taking thyroid won't increase your metabolism arbitrarily (I don't think), it only restores it to normal when your metabolism is impaired due to dieting. Even so, I think you must be correct that SGBH will increase.

This stuff is too difficult, and I'm not interested in screwing with my thyroid right now anyway. Going back to minding my own business. :)

posted by AMERFOOTBALL

LOL. actually taking t3 will increase metabolism. how much? depends on dosage. you can take t3 during bulking if you eat enough, you will put on mass, it will also be lean mass.

posted by ReMaDe

little confused, but great info, if t3 acctually raises you metabolism wouldnt be great diet suppliment by itself, for someone who is looking to cut?

posted by illsniggles

it eats muscle though... a lot of people do Test/T3

posted by Dex

do T4 then

posted by AMERFOOTBALL

t3 will raise metabolism, but it does not discriminate between fats or protiens. meaning it will burn muscle just as well as fat. that is why many people run AAS with t3. also it does shut down natural thyroid function so much so that if you don't do a ton of high intensity cardio and properly carb load when coming off of t3, you will put on massive amounts of fat.

posted by AMERFOOTBALL

IMHO, t4 will not spare muscle. the body convert t4 to t3 so i don't see how it would be muscle sparing....

posted by illsniggles

Right, T4 converts to T3, so there's no reason to get T4.

posted by Dex

just heard T4 isnt as bad as t3

posted by AMERFOOTBALL

t4 is weaker than t3. that is correct, but t4 converts to t3. the tricky part is that it converts at different rates in each person. so taking 100mcg of t4 for you may equal 25mcg of t3 for you but 100mcg of t4 for me may equal only 18mcg for me. IMHO, its better to run t3, that way you know how much you are getting. T4 made its way into the market because sources are looking for profit. its cheap and readily available. they market it as a safer alternative to t3 and bingo they sell an assload of it.

posted by Dex

cellucor has some stuff called T7(thyroid). take that with their D4 (eca) and it works awesome. i have yet to try anything like t3, clen, etc...

posted by illsniggles

everytime amer posts i think its that kid, not him

posted by Dex

i do the same haha

amer, your arms are lookin huge

posted by AMERFOOTBALL

thanks to ab, you guys can now take me serious again!

posted by estray

Glad to see you got control of yourself. Hahahaha.

posted by illsniggles

I dunno i still see a fat-retarted-red haired-freckle covered-hick-fat-retarted kid, amer. lol jk

posted by AMERFOOTBALL

you got the fat part right at least!

posted by cowcountry

T4 often doesn't convert to T3 in hypothyroid patients because of a lack of 5-deiodinase in the liver and kidneys. However, exogeneous administration of T4 can lead to an increas of TSH levels which in turn will make the T3 most effective. In plain english, take both T3 and T4 in conjunction with each other for best results.

I really don't have any input on the Proviron regime...

posted by illsniggles

Hmmm i dunno, almost everyone i know takes T3 with Test to minimize muscle loss. To each his own, though.

posted by Dex

so take t3, t4, and test

posted by cowcountry

I'm right there with ya, just haven't even put .02 cents worth of thought into the proviron regime.

posted by AMERFOOTBALL

interesting point cc. i guess i was assuming that if you were hypo, you'd already be on thyroid hormones under a docs care. but this may explain why ive heard of hypthyroid patients continuing to show symtoms of it even after starting synthroid. Theres more research to be done on my part I guess.

posted by Dex

Thyroid hormone synthesis and secretion is regulated by the hypothalamic-pituitary-thyroid axis. Thyrotropin-releasing hormone (TRH) released from the hypothalamus stimulates secretion of thyrotropin-stimulating hormone, TSH, from the anterior pituitary. TSH, in turn, is the physiologic stimulus for the synthesis and secretion of thyroid hormones, L-thyroxine(T4) and L-triiodothyronine (T3), by the thyroid gland. Circulating serum T3 and T4 levels exert a feedback effect on both TRH and TSH secretion. When serum T3 and T4 levels increase, TRH and TSH secretion decrease. When thyroid hormone levels decrease, TRH and TSH secretion increase.
The mechanisms by which thyroid hormones exert their physiologic actions are not completely understood, but it is thought that their principal effects are exerted through control of DNA transcription and protein synthesis. T3 and T4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins.
Thyroid hormones regulate multiple metabolic processes and play an essential role in normal growth and development, and normal maturation of the central nervous system and bone. The metabolic actions of thyroid hormones include augmentation of cellular respiration and thermogenesis, as well as metabolism of proteins, carbohydrates and lipids. The protein anabolic effects of thyroid hormones are essential to normal growth and development.
The physiologic actions of thyroid hormones are produced predominately by T3, the majority of which (approximately 80%) is derived from T4 by deiodination in peripheral tissues. Levothyroxine, at doses individualized according to patient response, is effective as replacement or supplemental therapy in hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis.
Levothyroxine is also effective in the suppression of pituitary TSH secretion in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, Hashimoto’s thyroiditis, multinodular goiter and, as adjunctive therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

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